Notably, ONC201, which is a well‐tolerated compound used in a Phase I/II study for patients with advanced solid tumor (NCT02038699) (NCT02324621),284 has been reported to downregulate CSC‐related genes, including ALDH1A1 and ALDH7A1, and suppress CSCs self‐renewal in CRC, PCa, and GBM cells.285. The gene discussed is ALDH1A1; the disease is colorectal carcinoma.