Interestingly, ALDH1A3 is highly expressed in mesenchymal glioma stem‐like cells (Mes‐GSCs) with a more aggressive phenotype, and the inhibition of ALDH1A3 attenuates the growth of Mes‐GSCs and sensitizes Mes‐GSCs to radiotherapy, suggesting that ALDH1A3 is a promising biomarker for Mes‐GSCs.17, 148, 149, 150. This evidence concerns the gene ALDH1A3 and central nervous system cancer.