A growing number of studies have revealed that the aberrant expression of ALDH1B1 has been observed in several human cancers such as CRC,154 pancreatic cancer,15 NSCLC,135 GC, and HCC,155 and it is involved in tumorigenesis and metastasis as well as clinical prognosis. The gene discussed is ALDH1B1; the disease is familial pancreatic carcinoma.