The mutant (rs1330286) genotype in ALDH1A1 is associated with a low risk of PCa, whereas the mutant (rs4646653) genotype in ALDH1A3 is strongly related to a high risk of PCa, indicating that genetic variants in ALDH1A1 and ALDH1A3 may play different roles in the tumorigenesis.127. The gene discussed is ALDH1A3; the disease is posterior cortical atrophy.