Further studies indicate that ALDH1A1 or ALDH1A3 as markers of GSCs may be correlated with distinct molecular subtypes of high‐grade glioma (HGG) tumors, with ALDH1A3 being a marker of the mesenchymal subtype17, 150, 151 and ALDH1A1 being a marker of the classical subtype.122. The gene discussed is ALDH1A3; the disease is central nervous system cancer.