Studies have established that ALDH1L1 is often strongly and universally downregulated or silenced in a multitude of human solid cancers, including HCC,162, 163, 164 lung adenocarcinoma (LUAD),165 ccRCC,166 neuroblastoma (NB),167 and breast cancer.168. The gene discussed is ALDH1L1; the disease is neuroblastoma.