Moreover, circ-IARS expression was reduced by 62.00% in xenograft tumor tissues than in the sh-circ-IARS group (Figure 6c), which was accompanied by 2.89-fold upregulation of miR-1252-5p and 65.00% downregulation of HDGF (Figure 6d and e). The gene discussed is HDGF; the disease is neoplasm.