NOTCH1 and neurodegenerative disease: The axon guidance pathway contains proteins related to synaptic dysfunction27 and the complement and coagulation cascades are an important pathway in innate immune responses previously identified in neurodegenerative diseases.24,28 Using co-expression clustering, we detected a module (MEturquoise) represented by the NOTCH1 protein, which has a reported Parkinson’s disease relationship as it is modulated by the LRRK2 protein.29 HPDG, the hub protein for the red module, is part of the prostaglandin signalling pathway with a role in neurodegeneration.