The same results were mentioned by others, who reported PCO in 52-82% of patients with adult acne [20], and by Borgia et al, who demonstrated PCO in 60 of 129 (46.51%) of patients, but the LH/FSH ratio was increased in only 19 of them, and the ultrasonographic evidence of PCO was not significantly associated with an increased LH/FSH ratio [22]. Here, PLOD1 is linked to acne.