Inevitably, supplementation of BAIBA lost the protective effects against hypertension, vascular remodeling and oxidative stress in SHR subjected to knockdown of either AMPKα1 or SIRT1 (Figure 6(a-f)), indicating the involvement of AMPK/SIRT1 signaling in mediating the effects of BAIBA in SHR. This evidence concerns the gene SIRT1 and hypertensive disorder.