Furthermore, deficiency of AMPKα1 and SIRT1 removed the protective effects of BAIBA on vascular fibrosis and inflammation in response to hypertension, as indicated by protein expressions of TGF-β1, collagen I, TNF-α, IL-1β, MCP-1, and IL-6 (Figure 7(d)). Here, TGFB1 is linked to hypertensive disorder.