NLRC5 and non-small cell lung carcinoma: Of note, transfection with pcCEACAM1 reversed the effects of NLRC5 knockdown on hypoxia-induced cell functions in NSCLC cells, and treatment with LY294002 alleviated the effects of CEACAM1 upregulation on hypoxia-induced cell functions in A549 cells (Figure 6(b-f)).