Importantly, the knockdown of NLRC5 decreased the IC50 value of carboplatin and suppressed the protein expressions of P-gp and MDR1 in A549/R and H1650/R cells compared with normal cells (figure 3(f, g)), implying that NLRC5 was sufficient to induce carboplatin-resistance in NSCLC cells. The gene discussed is NLRC5; the disease is non-small cell lung carcinoma.