Importantly, the knockdown of NLRC5 increased the chemosensitivity of NSCLC resistant cells to carboplatin, as evidenced by increased cell viability, a lower IC50 value and protein expressions of P-gp and MDR1, which were reversed by CEACAM1 overexpression (figure 5(f-h)). The gene discussed is PGP; the disease is non-small cell lung carcinoma.