TNFRSF4 and neoplasm: Taken together, we hypothesized that in responders, highly expressed OX40L in the TME enhanced the recruitment of activated NK cells with high expression of OX40 into the tumor, and then OX40-OX40L interaction between NK-T, and NK-DC cells might augment anti-tumor immunity by increasing T cell survival and activation, as well as development of memory T cells.