BMI1 and neoplasm: Several loci that enhance Myc/Pim kinase tumor development have already been identified, including Pal-1/Gfi-1 (Growth Factor Independent 1 Transcriptional Repressor), Bmi-1 (B Lymphoma Mo-MLV Insertion Region 1 Homolog), and Runx2 (RUNX Family Transcription Factor 2) [18, 26, 27].