PIM1 and leukemia: The cooperation between Pim and myc in the generation of leukemia/lymphoma is well documented: Pim-1/myc transgenic mice develop pre-B-cell leukemia at high frequency [16], c-Myc/N-Myc enhances Pim-1 development of T-cell lymphoma in utero [22], and Pim-2/c-Myc mice develop pre-B-cell, B-cell, and T-cell lymphomas [23].