Pim-2 expression is up-regulated in MM cells through IL-6/JAK2/STAT3 and TNFα/NF-κB mediated pathways and inhibitors to either STAT3 (cucurbitacin I) or IKKα/β (I-Kappa-B Kinase)(parthenolide) decrease Pim-2 expression [110]. This evidence concerns the gene CHUK and Miyoshi myopathy.