Most NHLs over-express Pim-1/Pim-2 – as an examination of patient samples from indolent and aggressive NHLs (MCL, DLBLC, FL, MZL-MALT, CLL, and NMZL) showed marked over-expression of Pim-2, and to a lesser degree, Pim-1, with Pim-3 levels similar to normal lymph node and tonsil tissues [113]. The gene discussed is PIM2; the disease is B-cell chronic lymphocytic leukemia.