Polymorphisms of angiotensinogen, apolipoprotein E (APOE), angiotensin-converting enzyme (ACE), endothelial nitric oxide synthase (eNOS), erythropoietin, interleukin-6 (IL-6), interleukin-10 (IL-10), catechol-O-methyltransferase (COMT), GRM7 | LMCD1—AS1 loci and BBS9, transducer and activator of transcription 3 (STAT3), and macrophage migration inhibitory factor (MIF) genes have been proven to be associated with a higher risk of AKI after cardiac surgery [100]. This evidence concerns the gene COMT and acute kidney injury.