Survival analyses showed that iCCA patients with high COL12A1 mRNA expression had a significant worse prognosis than iCCA patients with low COL12A1 mRNA expression from TCGA, E-MTAB-6389 or OEP001105 cohort (Fig. 3C), and the corresponding optimal cutoff value for dividing iCCA patients into COL12A1 mRNA-high/low expression (log2 expression) group was 11.375 in TCGA cohort, 6.02 in E-MTAB-6389 cohort and 5.255 in OEP001105 cohort, respectively. This evidence concerns the gene COL12A1 and infantile convulsions and choreoathetosis.