Brucella melitensis M5-90 infection induced 777 DEmiRNAs in goat fibroblasts, and targets for these DEmiRNAs were predicted to function in immune responses (e.g. cytokine-cytokine receptor interaction, natural killer cell-mediated cytotoxicity and Toll-like receptor signaling pathway, TNF signaling pathway, MAPK signaling pathway and JAK/STAT signaling pathway) [56]. This evidence concerns the gene TNF and infection.