In prepubertal girls, the responses to central obesity include also a decrease in circulating sex hormone-binding globulin (SHBG) and adiponectin, which may be followed by an early and amplified adrenarche, with high levels of its marker, dehydroepiandrosterone-sulfate (DHEAS), and by the appearance of pubic (pubarche) and/or axillary hair, acne and pubertal odor before age 8 years [26–28]. The gene discussed is SHBG; the disease is acne.