In addition, it is noted that the downregulation of PD-L1 can be found in the cell adhesion molecule pathway and downregulation of PD-1 can be found in the T cell receptor signaling pathway, and the D-L1 expression and PD-1 checkpoint pathway in the cancer pathway was also downregulated (Supplementary Figs 2 A, 4 A, 5 B). This evidence concerns the gene DLL1 and cancer.