Consistently, DOC-2/DAB2 interactive protein (DAB2IP) can form a complex with PARP-1 and its identified E3 ligase in renal cell carcinoma (e.g., RanBP2, TRIP12, RNF40, and VHL), leading to PARP-1 degradation. This evidence concerns the gene DAB2IP and hereditary clear cell renal cell carcinoma.