The IL-1β levels in the supernatants of irradiated BEAS-2B, H446, A549, and H460 cells at different time points were detected by ELISA, and the results showed that irradiated BEAS-2B cells secreted significantly higher amounts of IL-1β compared with irradiated lung cancer cells, which was most evident 48 h post radiation. The gene discussed is IL1B; the disease is lung cancer.