POSTN and atopic eczema: Our follow-up study, with a similar design to Nanishi’s et al [42], although conducted at a single center, with smaller sample size and with nasal rather than serum periostin detection, found, on the contrary, an inverse association between periostin detection and the development of asthma by age 4 years, independently of atopic risk factors such as atopic dermatitis or family history of asthma or atopy.