T2DM leads to cardiac stiffness, myocardial fibrosis and hypertrophy by multiple mechanisms, such as hyperglycemia, systemic and cardiac insulin resistance, calcium disturbance in cardiomyocytes, inflammation, microvascular dysfunction and so on [21, 22], which put tremendous stress on the heart independently to other risk factors [23, 24]. The gene discussed is INS; the disease is Hyperglycemia.