There were no significant differences between patients with positive and negative BM CD30 regarding gender, age at the start of the symptoms, age at diagnosis, x-ray findings, DEXA results, skin involvement, lymphadenomegaly (LAM), cardiovascular symptoms, GI tract symptoms, skin symptoms, ascites, portal hypertension, anaphylaxis, B symptoms, bone symptoms or mortality. This evidence concerns the gene TNFRSF8 and portal hypertension.