C9orf72 and amyotrophic lateral sclerosis: For the classification of an ALS frontal cortex sample to a specific ALS type (sporadic ALS or C9orf72-related ALS), apart from the C9orf72 gene, among the topmost determinative genes was also ATP2A1, a gene associated with glucose metabolism, related to the downregulation of Muscular differentiation and proliferation in ALS (Silroy and Bhowal 2018).