IL-8 levels are low in healthy and benign breast tumor tissues and high expression of IL-8 in breast cancer tissues has nothing to do with age and clinical stages, but correlated with the histological type (invasive and non-invasive carcinomas) and lymph node metastasis, thereby distinguishing benign and malignant breast tumors16,17,29. This evidence concerns the gene CXCL8 and breast cancer.