TNF and neoplasm: As expected, ferroptotic and necroptotic pathways played key roles, as evidenced by reduced levels of various immune cells in the tumor microenvironment (TME) and reduced expression of an early activation marker (CD69) and effector cytokines (IFN-γ and TNF-α) by tumor-infiltrating CD8+ and CD4+ T cells in Acsl4-/-, Ripk3-/- and Mlkl-/- mice.