Additionally, in a separate group from the ipGTT considered for dissection (at 28 weeks of age), C3H.NSY-Nidd5nsy mice exhibited significantly higher body weights (P < 0.01), BMI (P < 0.05), and visceral fat weights (P < 0.05) than C3H mice, suggesting that increases in body fat and insulin resistance were the main causes of hyperglycemia induced by Nidd5nsy. The development of hyperglycemia in the face of insulin resistance with normal insulin secretion suggests the failure of insulin secretion to compensate for insulin resistance. This evidence concerns the gene INS and Insulin resistance.