Adoptive transfer of Gal-7-conditioned MDSCs accelerated skin carcinogenesis in Lgals7−/− mice, whereas depletion of these cells using an anti-DR5 mAb delayed appearance of papillomas in Tg46 mice, thus emphasizing the essential contribution of MDSCs to Gal-7-driven skin carcinogenesis. This evidence concerns the gene TNFRSF10B and papilloma.