To gain insights into the mechanisms underlying Gal-7-induced skin carcinogenesis, we next performed RNA-seq analysis in WT, Lgals7−/− and Tg46 mice skin papillomas, which revealed clusters of 240 and 264 genes differentially expressed in distinct mouse strains (Fig. 3A, B, and Supplementary RNAseq Datasheet 1). Here, LGALS7B is linked to skin papilloma.