A substantial increase in the number of Ki67+ cells, indicative of proliferative activity, was detected in papillomas from Tg46 compared to WT or Lgals7−/− mice at the end of the carcinogenesis process (Fig. 2D), which was accompanied by altered expression of K10 (a suprabasal restricted keratin), but not of the basal-restricted K14 (Fig. 2E). The gene discussed is KRT14; the disease is papilloma.