Seeking for possible mechanisms underlying the increased myeloid cell representation in the tumor microenvironment (TME) and tumor-dLN of Tg46 mice, we examined RNAseq data, which revealed increased transcription of chemokine and cytokine genes implicated in myeloid cell recruitment in lesions from Tg46 compared to those from WT mice (i.e., Cxcl1 and VEGFa), and in papillomas from WT mice compared with their KO counterpart (i.e., Cxcl1, Ccl7 and Clcc1; Fig. 4A). This evidence concerns the gene VEGFA and papilloma.