LGALS7 and skin papilloma: To gain insights into the mechanisms underlying Gal-7-induced skin carcinogenesis, we next performed RNA-seq analysis in WT, Lgals7−/− and Tg46 mice skin papillomas, which revealed clusters of 240 and 264 genes differentially expressed in distinct mouse strains (Fig. 3A, B, and Supplementary RNAseq Datasheet 1).