Papillomas from anti-DR5 mAb-treated Tg46 mice showed reduced frequency of M-MDSCs and increased proportion of PMN-MDSCs, leading to a significant drop in the M-MDSC/PMN-MDSC ratio (Fig. 7I), and higher T effector/Treg ratio (CD8+/CD4+CD25+Foxp3+ ratio), indicative of greater effector T-cell responses, compared to those treated with the control mAb (Fig. 7J). Here, CD4 is linked to papilloma.