MET and papilloma: Given the association between c-Met pathway activation and Cxcl1-mediated recruitment of myeloid cells to the TME [49], the identification of mutated c-Met as a prominent cancer driver gene in Tg46 mouse papillomas (Fig. 4C, D) and the higher percentage of Cxcl1+ cells in these tumors (Fig. 4B), we then explored if abnormal c-Met activation could be responsible for the increased expression of Cxcl1.