Analysis of tumor infiltrating cells revealed a higher M-MDSC frequency (% of Ly6ChiLy6Glo cells from infiltrating CD11b+ cells; Fig. 7D and Supplementary Fig. S3E) and a greater percentage of Tregs (CD25+Foxp3/CD4+cells), which led to a lower CD8+/CD4+CD25+Foxp3+ ratio, indicative of attenuated T cell responses (Fig. 7E and Supplementary Fig. S3E) in papillomas from Lgals7−/− animals receiving M-MDSC-Gal-7 compared with those receiving M-MDSC-C. The gene discussed is CD4; the disease is neoplasm.