CD4 and infection: 2) ODC-1 levels do not correlate with Treg/Th17 ratio in PLWH (Supplementary Fig. 19), while ODC-1 inhibition significantly diminishes Treg/Th17 ratio in cultures, 3) CD4+ T cells from PLWH on cART show increased HIF-1α expression, but in vitro infection doesn’t upregulate HIF-1α in CD4+ T cells.