More work and fresh clinical samples are needed to determine the expression of ODC-1, EIF5A, Hyp-EIF5A specifically in Th17, Treg, and TregDys in PLWH to achieve a complete understanding of how ODC-1-polyamine-EIF5A hypusination and the auto-regulatory loop impacts Th cells during viral infections. This evidence concerns the gene ODC1 and viral infectious disease.