Hi-C data supported that 63 of them were linked to the promoter of the BIN1 gene(see Fig. 4c), which validated the roles of AD-associated SNPs in the activity of BIN1. Among AD-associated SNPs within or surrounding the BIN1 gene, rs4663105 was the most associated SNP, with a significance of p = 1.45e-44. Here, BIN1 is linked to Alzheimer disease.