CD274 and neoplasm: The resultant p(NIPAAm)589-co-(BA)117, with an LCST of −4.4 ± 0.6 °C that is close to the temperature on the outer surface of a frozen tumor iceball, was selected to synthesize the CRNPs for co-encapsulating irinotecan (CPT, a clinically used chemotherapy drug) and programmed death-ligand 1 (PD-L1) silencing siRNA (siR) using a double-emulsion method (Fig. 1).