Mutations in the cohesin complex were significantly associated with normal karyotypes (66.8% vs. 49.6%, p < 0.001), mutated TET2 (25.0% vs. 18.5%, p = 0.046), ASXL1 (17.9% vs. 7.1%, p < 0.001), and SRSF2 (16.8% vs. 5.0%, p < 0.001), while inframe mutations in CEBPA-bZIP (7.6% vs. 9.1%, p = 0.008) and mutated IKZF1 (0% vs. 3.2%, p = 0.007), TP53 (2.7% vs. 7.7%, p = 0.009), complex karyotypes (6.0% vs. 12.4%, p = 0.022) and inv [16] or t(16;16) were rare (0.5% vs. 4.0%, p = 0.016) compared to cohesin wild-type AML. The gene discussed is SRSF2; the disease is acute myeloid leukemia.