CPT1C and breast cancer: Accordingly, CPT1C downregulation by siRNAs in colon cancer (HCT116), breast cancer (MCF7, Hs578T), lung carcinoma (A549), pancreatic carcinoma (PANC-1), and thyroid carcinoma (KTC-1 and B-CPAP) cell lines increases cell death in response to different stressors, such as hypoxia, glucose depletion, glycolysis inhibition, and rapamycin treatment (which mimics amino acid-like starvation) [14, 24, 27].