DCN and cancer: Important proteoglycans that are upregulated in cancer include syndecans (67, 68), glypicans (69), perlecans (70, 71, 72), agrins (61, 73, 74, 75, 76, 77), small leucine-rich proteoglycans (SLRPs) such as biglycans (78, 79), lumicans (80, 81, 82, 83), and decorin (84).