Our eQTL colocalization analyses also showed that the proinsulin signal at the NKX6-3/ANK1 locus does not colocalize with the primary AGEN T2D signal and NKX6-3 in islets but rather with the secondary AGEN T2D signal and the ANK1 eQTL in adipose.26 Here, ANK1 is linked to type 2 diabetes mellitus.