It is worth mentioning that TLR2 deficiency significantly reduced the productions of IL-6, TNF-α and IL-4, while promoted IFN-γ production, the severity of liver fibrosis was reduced, suggesting that IL-6, TNF-α, IL-4 and IFN-γ were regulated by TLR2 and could be involved in the pathogenesis of biliary fibrosis induced by C. sinensis. This evidence concerns the gene TNF and Hepatic fibrosis.