INS and malignant colon neoplasm: Transcripts associated with mitochondria and the proteasome (Polyamine Regulation in Colon Cancer) were enriched in the morning/evening population, while those associated with the cytoskeleton and calcium signaling (RAR Activation, Insulin Secretion Pathway, VDR/RXR Activation) peaked in the afternoon/night (Fig 1G and S7 File).