The potential shared indications forCB1 and CB2 agonists include pain,24 anxiety,25 neurodegenerative disorders,26 cancer,27 emesis, and nausea.28 Of note, there are some conditions such as addiction,29 systemic sclerosis,30 atherosclerosis,31 obesity,32 or diabetes,33 whereCB1 antagonists can be successfully replaced with CB2 agonists withoutseriously compromising the therapeutic outcome. The gene discussed is CNR2; the disease is atherosclerosis.