CNR2 and osteoarthritis: What is more, in somediseases that are characterized by a prominent inflammatory component(e.g., rheumatoid arthritis or osteoarthritis), CB2 activation mayseem the preferred mechanism of action.34−36 Finally, CB2 antagonistscould aid in tackling some conditions like renal fibrosis37 and immunoparalysis.38 Additionally, apart from the broad spectrum of potential indications,CB2 ligands lack the typical CB1-related psychotropic adverse effects,6 which makes them desired potential drug candidates.