Biogenesis of lysosome-related organelles complex 1 (BLOC-1) component aggregation, followed by loss of functioning has also been linked with dysbindin-1 overexpression, which could result in loss of Arp2/3 regulation, might contribute directly to dendritic pathology in schizophrenia [86]. This evidence concerns the gene DTNBP1 and schizophrenia.