Normally, the epitope consists of an 8 to 10 or 12 to 18 amino-acid-long peptide fragment of antigens that are only or more expressed in cancer cells, either TSA or TAA, and is ideally designed optimal for internalisation by dendritic cells and antigen presentation on MHC molecules, delivering CD8+ or CD4+T cell activation, respectively (Hines and Marschall 2018). The gene discussed is CD8A; the disease is cancer.