METTL3 and acute myeloid leukemia: Accordingly,METTL3 downregulation led to cell cycle arrest and differentiation.Interestingly, METTL3 was shown to associate with chromatin independentlyfrom METTL14 and bind to specific promoters, such as those of transcriptionfactors SP1 and SP2, where it methylates the mRNA of AML-associatedgenes and finally enhances their translation.123 Vu et al. further showed that METTL3 knockdown in humanhematopoietic stem/progenitor cells (HSPCs) induces differentiationand impairs proliferation.