Notably, METTL3 activity has beenmostly linked to tumor-promoting functions, although in some contextsMETTL3 acts as a tumor suppressor, as summarized in Tables 2 and 3 and in Figure 2.The properties of METTL3 as either a tumor promoter or suppressorhave been linked to the status of p53.92 In response to DNA damage or oncogenic signals, METTL3 was shownto interact with and stabilize the oncosuppressor p53 and to introducethe m6A modification to the transcripts of several p53target genes. Here, TP53 is linked to neoplasm.