Mechanistically,METTL3 was shown to be essential for translation and ribosome biogenesis.Specifically, METTL3 methylates the mRNA encoding for the pescadillohomologue (PES1), a protein involved in the maturation of the 60Sribosomal subunit and cell cycle progression that was found to actas an oncogene in several cancers.126 Moreover,cytoplasmic METTL3 was proposed to act as a reader and to furthersupport PES1 translation in a similar manner to that described inthe lung cancer context.108. This evidence concerns the gene METTL3 and cancer.