METTL3 and neoplasm: Moreover, METTL3 was found to induce radiotherapyresistance through SOX2-dependent increased DNA repair, thereby actingas a key tumor promoter in glioblastoma.101 Conversely, Cui et al. found contrasting results, correlating alow expression of METTL3 in glioblastoma cells with a persistent stem-likestate and increased GSC growth and self-renewal.102 Moreover, these alterations are correlated with the upregulationof oncogenic proteins such as ADAM19, EPHA3, and KLF4 and the downregulationof oncosuppressors such as CDKN2A, BRCA2, and TP533I11 in GSCs.