In moredetail, 3b displayed cancer-selective micromolar to submicromolarantiproliferative activity values in a panel of various AML cell lines,along with increased lifespan, no significant weight variations, andno toxicity in AML PDX mouse models.132 These experiments highlight the efficacy of the pharmacologicalinhibition of METTL3 in AML. This evidence concerns the gene METTL3 and cancer.