Moreover, in MOLM-13AML cells, METTL3-mediated mRNA methylation increases the translationof c-Myc, Bcl-2, and PTEN.124 METTL14 was also found to be overexpressed in HSPCs and in AML cellscarrying t(11q23), t(15;17), or t(8;21) translocations, while itssilencing induced the differentiation of both HSPCs and AML cellsalong with the inhibition of AML cell proliferation. This evidence concerns the gene PTEN and acute myeloid leukemia.