Accordingly, the treatment with the known antidiabeticmetformin led to lower levels of m6A on p21 transcripts,resulting in higher p21 expression and reduced tumor size in a mousebreast cancer model.94 Furthermore, METTL3was shown to methylate Bcl-2 transcripts, thereby facilitating thetranslation of this antiapoptotic factor. This evidence concerns the gene BCL2 and neoplasm.