Analogues of 7a were reported in a subsequent patent, which included pyrido[1,2-a]pyrimidinone derivatives linked to an indole moiety viaa carbamoylmethyl linker (7b–f, whichpossess the same core as 3b), the deuterated analogueof 7b (7b-D), and the thiazolo[3,2-a]pyrimidinone derivative 7g (Figure 8B).131 All compounds inhibited METTL3 enzymatic activity with an IC50 value of 6.1 nM and impaired the proliferation of the Caov-3cells (IC50 values between 80 (7d) and 237nM (7b)) and the AML cell line Kasumi-1 (IC50 values between 263 (7d) and 587 nM (7b)). Here, METTL3 is linked to acute myeloid leukemia.