Mechanistically, 13 was shown to promote METTL3 degradation by facilitatingits interaction with the ubiquitin E3 ligase STIP1 homology and U-Boxcontaining protein 1 (STUB1), as confirmed by both Western blot andfunctional experiments performed on ESCC cells.127. This evidence concerns the gene METTL3 and esophageal squamous cell carcinoma.