In the contextof neurodegenerative disorders, a recent study onAlzheimer’s disease (AD) mouse models showed reduced m6A methylation in AD-related genes along with slightly decreasedMETTL3 expression and increased FTO levels (Table 1).91 These studiesindicate that disruption in the METTL3/FTO axis and consequent alterationof m6A methylation patterns influence multiple neurologicalpathways ranging from dendritic and synaptic development to long-termpotentiation, finally strongly linking the alteration of RNA methylationto neurological pathologies. This evidence concerns the gene METTL3 and Alzheimer disease.