A recentstudy by Liao et al. indicated that METTL3 is upregulatedin esophageal squamous cell carcinoma (ESCC) cells and metastatictissues and that its activity is correlated with cancer metastasis.127 Cellular and in vivo experimentsindicated that METTL3 methylates the early growth response protein1 (EGR1) mRNA and activates the EGR1/Snail signaling, which in turnpromotes metastasis. The gene discussed is EGR1; the disease is esophageal squamous cell carcinoma.