METTL3 and colorectal carcinoma: miR-1246 isknown to inactivate the oncosuppressor SPRED2, thus leading to itsdownregulation and consequent activation of the RAF/MEK/ERK pathwaythat supports cancer cell migration and metastasis.99 On the other hand, METTL3 was shown to impair proliferation,migration, and invasion in CRC cells, and its downregulation was associatedwith higher expression of phosphorylated p38 and ERK (p-p38 and p-ERK,respectively) and the consequent activation of the p38 and ERK signalingpathways.100