Moreover, METTL3 was found to induce radiotherapyresistance through SOX2-dependent increased DNA repair, thereby actingas a key tumor promoter in glioblastoma.101 Conversely, Cui et al. found contrasting results, correlating alow expression of METTL3 in glioblastoma cells with a persistent stem-likestate and increased GSC growth and self-renewal.102 Moreover, these alterations are correlated with the upregulationof oncogenic proteins such as ADAM19, EPHA3, and KLF4 and the downregulationof oncosuppressors such as CDKN2A, BRCA2, and TP533I11 in GSCs. Here, SOX2 is linked to glioblastoma.