Indeed, the implications of METTL3 activity are controversialin some contexts such as breast cancer, CRC, and glioblastoma, whereit seems to have a dual role, and METTL3 has crucial physiologicalroles in cell cycle regulation, differentiation, and neural development.Furthermore, the inhibition of the m6A erasers FTO andALKBH5 has been shown to be beneficial in cancers such as glioblastoma,breast cancer, pancreatic cancer, and AML. This evidence concerns the gene METTL3 and familial pancreatic carcinoma.