METTL3 and acute myeloid leukemia: Compounds 9a–d, bearing a cyclopentane-1,2-diolcore linked to a 6-amino-7-deazapurine at C3 and an indol-6-yl moietyat C5 (Figure 8D),displayed single-digit IC50 values for METTL3 inhibition(IC50 (9a) < 6 nM, IC50 (9b) = 6.1 nM, IC50 (9c) = 6.1 nM,and IC50 (9d) = 6.22 nM).138 Similar to other compound series from Storm Therapeutics,these compounds were tested for their influence on the ovarian cancerCaov-3 and AML Kasumi-1 cell proliferation, with IC50 valuesin the 250–556 nM range for Caov-3 and those in the 0.95–1.39μM range for Kasumi-1.