METTL3 and neoplasm: Recentstudies demonstrate a correlation among high METTL3 levels,low FTO and ALKBH5 levels, poor prognosis, and advanced tumor stageand grade in gastric cancer.103 Accordingly,the downregulation of METTL3 causes an increase in pro-apoptotic proteinlevels, including Bax and caspase-3, and at the same time a decreasein oncogenic proteins like Bcl-2.