GLI1 and Familial prostate cancer: For example, in ovarian cancer, the dysregulation of METTL3triggers EMT, leading to the cancer cell proliferation and invasion.114 In prostate cancer, METTL3 is overexpressedand the methylation of the mRNA encoding for GLI family zinc finger1 (GLI1) increases the expression of this protein, which supportsandrogen-independent growth.