These models include the bladder cancer line 639V (PRKACA copy number gain Barretina et al., 2012) and Colo741 skin and ML1 thyroid (PRKAR1A frameshift mutations Ghandi et al., 2019) lines; of note, Colo741 was derived from a patient with colon cancer but is thought to be a melanoma (Vincent and Postovit, 2017). The gene discussed is PRKACA; the disease is urinary bladder cancer.