A prototypical example is the PRKACA L205R mutation, which generates an unregulated PKAc variant found in adrenocortical and ACTH(Adrenocorticotropic Hormone)-producing pituitary tumors in patients with Cushing’s syndrome (Cao et al., 2014). This evidence concerns the gene POMC and Cushing syndrome due to macronodular adrenal hyperplasia.