For brain MRI findings, seven genes on 9p, and four genes on 18p were matched to hypoplasia of corpus callosum (SMARCA2, KIAA0020, NFIB, GLDC and FREM1 located at 9p and TGIF1, TYMS, ENOSF1 located at 18p, Figure 5A,C), cavum septum pellucidum (TGIF1, Figure 5C), enlarged sylvian cistern (KANK1 and MPZ located at 9p and TGIF1, Figure 5B,C), delayed myelination (no matching was found) and trigonocephaly (FREM1, TGIF1, ENOSF1 and NDC80, Figure 5A,C). The gene discussed is KANK1; the disease is trigonocephaly.