TANs in NASH-HCCs also release NETs that, through the engagement of Toll-like receptor 4 (TLR4), mediates a reprogramming of naïve CD4+ T-cells to CD4+/FOXp3+ Tregs capable of counteracting CD8+ T-cell functions [40] (Figure 1). This evidence concerns the gene CD4 and metabolic dysfunction-associated steatohepatitis.