CD8A and metabolic dysfunction-associated steatohepatitis: In particular, the lack of iNKT cells in Jα18−/− mice or the block of iNKT cells with retinoic acid receptor-γ agonist tazarotene reduces CD8+ T-cell infiltration in NASH livers [78], suggesting a strict interplay between cytotoxic T-cells and iNKT cells in the mechanisms supporting steatohepatitis.