CD8A and hepatocellular carcinoma: HIF1α might have additional roles in modulating TAM function in HCCs as Wu et al. [158] have reported that in HCC patients HIF1α stimulates the macrophage expression of the pro-inflammatory modulator Trigering Receptor Expressed on Myeloid cells-1 (TREM-1) and that TREM-1 positive TAMs recruit immunosuppressive Tregs to HCC, leading to both reduced infiltration of CD8+ T-cells and poor survival.