However, IgA-producing plasma cells are detectable in the livers of mice carrying the hepatocyte-specific deficiency for T Cell Protein Tyrosine Phosphatase (TCPTP) (AlbCrePtpn2fl/fl) that develop extensive NASH when fed with a high-fat diet [86]. The gene discussed is PTPN2; the disease is metabolic dysfunction-associated steatohepatitis.