We have shown in fact that SerpinB3 (SB3), a HIF2α-regulated serine protease inhibitor, acts as a pro-inflammatory mediator in the progression of experimental NASH stimulating the infiltration of TREM-2+ macrophages and the up-regulation of pro-inflammatory cytokines [157]. This evidence concerns the gene TREM2 and metabolic dysfunction-associated steatohepatitis.