Moreover, among the genetic factors predisposing to MAFLD/NAFLD in the different ethnicities the rs738409 polymorphism in patatin-like phospholipase domain containing 3 (PNPLA3) appears the most common risk factor associated to the disease progression to advanced fibrosis and HCC [7,9]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.