Recently, Dudek et al. [100] have characterized NASH-associated CD8+ T-cells showing that these cells feature C-X-C motif chemokine receptor 6 (CXCR6), effector molecules and the programmed cell death protein 1 (PD-1), this latter suggesting an activated/exhausted phenotype. The gene discussed is CXCR6; the disease is metabolic dysfunction-associated steatohepatitis.