Of note, the hepatic accumulation of ihTh17 correlates with the extent of hepatocellular damage in both experimental and human NASH [97], while the adoptive transfer of ihTh17 cells induces hepatic injury in immunocompromised Rag2−/− mice receiving high-fat diet which are normally protected from NASH [98]. This evidence concerns the gene RAG2 and metabolic dysfunction-associated steatohepatitis.