Interestingly, MDSCs are increased in NASH livers as well as in NASH-HCC [123,125] since low-grade inflammation and metabolic derangements stimulate the activation of the cell cycle-related kinase (CCRK)/mammalian target of the rapamycin complex 1 (mTORC1) that enhances the recruitment of MDSCs (Figure 1). The gene discussed is CDK20; the disease is metabolic dysfunction-associated steatohepatitis.