Although a study by Imtiyaz et al. [156] has shown that macrophage HIF2α modulates the expression of CXCR4, M-CSFR, and fibronectin 1 (FN1) favouring macrophage tumor infiltration, our data suggest a possible additional contribution of hepatocyte-derived factors in modulating TAM recruitment in NASH-derived HCCs. This evidence concerns the gene EPAS1 and metabolic dysfunction-associated steatohepatitis.