CXCR2 and hepatocellular carcinoma: Moreover, recent studies have evidenced further heterogeneity in tumor-associated neutrophils (TANs) isolated from NASH-HCC showing that these cells are specifically characterized by high expression of the chemokine receptor CXCR2 and the carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8; CD66b) [66].