In this study, we uncover a TGFβ‐induced activation of FMNL2 via its phosphorylation by PKCα and/or PKCβ and show that FMNL2 is necessary for TGFβ‐induced cancer cell invasion into 3D matrices and the secretion of the pro‐metastatic factor Angiopoietin‐like 4 (ANGPTL4).[20, 21] Structured illumination microscopy (SIM) in living cells revealed that FMNL2 directly polymerizes actin on mobile ANGPTL4‐containing vesicles in a highly dynamic manner for their proper intracellular trafficking and subsequent secretion. The gene discussed is TGFB1; the disease is cancer.