In a cohort of convalescent patients of the first wave of COVID-19, we confirmed the results of computer modeling and demonstrated a higher persistence of immunoprevalent epitopes from ORF1ab gene of SARS-CoV-2 in HLA-A*01:01 carriers compared to epitopes from this gene in HLA-A*02:01 carriers. The gene discussed is HLA-A; the disease is COVID-19.