In lung adenocarcinoma-derived MPE, the methylation positive rates were 91.9% for SHOX2 and 59.5% for RASSF1A, which were different from those in a previous study using histology specimens, 54.9% for SHOX2 and 46.3% for RASSF1A in adenocarcinoma [18]. This evidence concerns the gene SHOX2 and adenocarcinoma.