BRAF and colon carcinoma: We also observed that AKAP95 (Figures 1(d1) and 1(e1)) and Elk-1 (Figure 1(e4)) were mainly expressed in nuclei in colon carcinoma tissue, whereas B-Raf (Figures 1(c2), 1(d2), and 1(e2)) and ERK1/2 (Figures 1(c3), 1(d3), and 1(e3)) subcellular localization were predominantly cytoplasmic.