ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Dasatinib, a targeted inhibitor of oncogenic breakpoint cluster region-Abelson leukemia virus (BCR-ABL) tyrosine kinase, has profoundly improved the outcome of chronic myeloid leukemia (CML) and Philadelphia-chromosome-positive acute lymphoblastic leukemia (Ph-ALL).