BIC is substrate for cytochrome P450-3A4 (CYP3A4) and uridine diphosphate glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1), but the mechanism of hyperbilirubinemia, though looks similar to cabotegravir, remains to be defined [14]. Here, CYP3A4 is linked to Hyperbilirubinemia.