In 1974, Levinson gave the first detailed description of DS as a little overt synovitis, associated with a gradual development of limitation of movement and appearance of deformities, absence of systemic features and normal or modestly elevated acute phase reactants (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)) and negative antinuclear antibodies (ANA) [3]. The gene discussed is CRP; the disease is synovitis.