In addition, several coagulation factors such as Factor 5 (F5, coagulation factor V; causative gene in Factor V Leiden thrombophilia), F8 and F12, which are part of the Intrinsic Prothrombin Activation Pathway, were up-regulated at 24 h in IS participants with poor 90d outcomes. Here, F5 is linked to Rare hereditary thrombophilia.