As expected, matrigel transwell assay showed that LARP6 knockdown promotes CRC cells invasion, but the enhancement is counteracted by expression recovery of ZNF267 and SGMS2, or treatment with the selective sphingomyelin synthase 2 inhibitor Ly93 [42, 43] (Fig. 6J-M, S4A [see Additional file 2]). The gene discussed is SGMS2; the disease is colorectal carcinoma.