In order to clarify the clinical significance of LARP6 dowen-regulated expression, we comprehensively analyzed clinical characteristics and LARP6 expression in IHC CRC cohort, and the results suggested that LARP6 expression is negatively correlated with T-stage, lymph node status, distant metastasis and clinical stage (Fig. 1F-G, Table S1) [see Additional file 2], but not with age, gender and tumor size (Table S1) [see Additional file 2]. Here, LARP6 is linked to neoplasm.