Certain endoscopic variceal stigma, collectively referred to as “red color sign” (red-whale markings, nipple symptoms, cherry-red spots), correlated with a significantly higher risk of acute variceal bleeding and re-bleeding [28]; hence, early preventive endoscopic treatment and shortening of the prothrombin time may decrease the occurrence of GIB [3]. Here, F2 is linked to Abnormal bleeding.