CYP7A1 and Hypercholesterolemia: It has been demonstrated that RELMα ameliorates HFD-induced hypercholesterolaemia and atherosclerosis by promoting the conversion of cholesterol into bile acids and mediating its subsequent fecal excretion via liver receptor homologue-1 (Lrh-1)-induced enhancement of hepatic cholesterol 7α-hydroxylase (CYP7A1) gene transcription [20].