In the RELM family, RELMα, RELMβ, and RELMγ are distributed in different tissues and cells, which have distinct biological functions including inflammatory response, cell proliferation, glucose metabolism, and body barriers, etc., and are involved in the regulation of different diseases such as lung diseases, intestinal diseases, cardiovascular diseases, and tumors and so on. The gene discussed is RETNLB; the disease is intestinal disorder.