In human bronchial epithelial cells (BECs), IL-13-induced RELMβ increases cells proliferation through phosphorylation of ERK1/2, PI3K, and Akt, and elevates the expression of a range of remodeling mediators, including transforming growth factor (TGF)-β2, epidermal growth factor (EGF), VEGF and MUC5AC, which contribute to airway remodeling in diseases such as asthma [60]. The gene discussed is EGF; the disease is asthma.